Computer code
Restricted Mean Survival Time

Uno H, Wittes J, Fu H, Solomon SD, Claggett B, Tian L, Cai T, Pfeffer MA, Evans SR, Wei LJ. Alternatives to Hazard Ratios for Comparing the Efficacy or Safety of Therapies in Noninferiority Studies. Annals of Internal Medicine 2015. 163(2),127-32.

Uno H, Claggett B, Tian L, Inoue E, Gallo P, Miyata T, Schrag D, Takeuchi M, Uyama Y, Zhao L, Skali H, Solomon S, Jacobus S, Hughes M, Packer M, Wei LJ. Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. Journal of Clinical Oncology 2014, 32(22):2380-2385.

Versatile Test

Uno H, Tian L, Claggett B, We LJ. A versatile test for equality of two survival functions based on weighted differences of Kaplan-Meier curves, Statistics in Medicine, 2015; 34(28):3680-95.

C-index for censored survival data

Uno H, Cai T, Pencina MJ, D'Agostino RB, and Wei LJ. On the C-Statistics for Evaluating Overall Adequacy of Risk Prediction Procedures with Censored Survival Data. Statistics in Medicine. 2011;30:1105-117.

R contributed package survC1 (example)

SAS version of survC1 contributed by Brian Starr

IDI/NRI with censored survival data

Uno H, Tian L, Cai T, Kohane IS, Wei LJ. A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data. Statistics in Medicine. 2013; 32(14):2430-2442. doi: 10.1002/sim.5647.

R contributed package survIDINRI (example)

Subject-Specific Incremental Values of New Maker

Uno H, Cai T, Tian L, and Wei LJ. Graphical Procedures for Evaluating Overall and Subject-Specific Incremental Values from New Predictors with Censored Event Time Data. Biometrics. 2011;67:1389-96.

R function

Integrated Difference of Two Survival Functions

Zhao L, Tian L, Uno H, Solomon S, Pfeffer M, Schindler J, Wei LJ. Utilizing the Integrated Difference of Two Survival Functions to Quantify the Treatment Contrast for Designing, Monitoring and Analyzing a Comparative Clinical Study. Clinical Trials. 2012;9(5):570-7

R code by Dr. Lihui Zhao

Time-dependent covariates

SAS program (by Yuuki Yoshida and Takenobu Tasaki)


  • Mantel and Byar. Evaluation of response-time data involving transient status: an illustration using heart-transplant data Kaplan Meier Curve. JASA 1974.
  • Simon and Makuch A non-parametric graphical representation of the relationship responder bias. Statistics in medicine 1984

Conditional probability curves

R code

Sample data

Predicted Interval Plots (PIPS)

Li L, Evans S, Uno H, Wei LJ. Predicted Interval Plots (PIPS): A Graphical Tool for Data Monitoring of Clinical Trials. Statistics in Biopharmaceutical Research. 2009;1(4):348-55

R contributed package PIPS (by Muenz D, Griner R, Evans S et al.)